GLP-1 side effects: GLP-1 medications, like Ozempic, Wegovy, and Mounjaro, have been making headlines for their role in weight management and type 2 diabetes. They can be life-changing, no doubt. But let’s be honest: they’re not without their downsides.
If you’re starting (or thinking about starting) one of these meds, it helps to know what you might run into along the way.
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Common side-effects of using GLP-1 drugs:
Most people hear about nausea first, and for good reason. It’s the most reported side effect, and it can range from mild queasiness to that “why did I even eat lunch” kind of feeling. Vomiting sometimes tags along, though not for everyone. Then there’s diarrhoea or constipation, depending on how your body reacts. Some people even get both at different times, lucky them.
You may also feel unusually full after eating very little. For some, that’s the point. But for others, it can feel uncomfortable, like fullness after just a few bites.
Beyond stomach issues, there are other things people don’t always bring up. Fatigue, headaches, or a general “off” feeling can creep in, especially early on. A few folks report changes in taste where suddenly your favourite coffee tastes like cardboard. And then there’s the infamous “Ozempic burp,” which, if you’ve heard of it, you know.
One thing to keep in mind: side effects often show up right after dose increases. Your body’s basically adjusting to a new rhythm, and sometimes it protests.
When to call a doctor?
Most side effects are tolerable and ease with time. But there are red flags you shouldn’t brush off. Severe abdominal pain that doesn’t let up? That’s not just indigestion, so call your doctor. The same goes for persistent vomiting or signs of dehydration. Rare, but serious, risks like pancreatitis and gallbladder issues are worth knowing about, even if they’re uncommon.
How to cope with the side effects of GLP-1 drugs?
Here’s the part everyone actually wants: what helps? Small, frequent meals are your friend. Greasy or super-rich foods tend to make nausea worse, so it’s not the best time for heavy pasta nights. Ginger tea, peppermint, or just plain crackers can be surprisingly effective.
Hydration matters more than you think. Sipping water throughout the day (not chugging it all at once) helps with nausea and digestion. And if constipation is the problem, fibre and gentle movements, like walking after meals, can make a big difference.
It’s also okay to slow down dose increases. Doctors often follow a set schedule, but if your body’s saying “nope,” let them know. Adjusting the pace can smooth out the bumps.
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GLP-1s aren’t a magic bullet, but they are powerful tools. Most side effects are temporary annoyances, not deal breakers. The key is knowing what’s normal, what’s not, and having a few tricks ready to manage the rough spots.
At the end of the day, your experience will be your own. Some people sail through; others need time to adjust. If it gets tricky, don’t white-knuckle it but talk to your doctor. There’s almost always a workaround.